What is the best alternative if the aortic valve cannot be repaired?

What Is the Best Research Globally?

Dr. Afshari’s editorial gives insight on human nature (1). Collaborative willingness usually occurs when different sides perceive personal benefit, or when institutions mandate collaboration. This is not unique between higher and lower income countries; many working in global emergency medicine (EM) observe this within wealthier countries. It exists among collaborators in low resource settings....

'Funny' current: if heart rate slowing is not the best answer, what might be?

What is the best approach in a patient with a failed aortic bioprosthetic valve: transcatheter aortic valve replacement or redo aortic valve replacement?

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether transcatheter aortic valve-in-valve replacement (viv-TAVR) or redo aortic valve replacement (rAVR) is the best strategy in a patient with a degenerative bioprosthetic aortic valve. Altogether, 162 papers were found using the reported search, of which 12 represented the bes...

Climatic changes: what if the global increase of CO(2) emissions cannot be kept under control?

Climatic changes threaten the planet. Most articles related to the subject present estimates of the disasters expected to occur, but few have proposed ways to deal with the impending menaces. One such threat is the global warming caused by the continuous increase in CO2 emissions leading to rising ocean levels due to the increasing temperatures of the polar regions. This threat is assumed to ev...

Simulating what cannot be simulated

The background to these notes is the expectation that mathematical modelling and simulation is going to play increasingly important role in the understanding of the organization and control of genetic-, metabolic-, and signalling pathways. I am going to argue that for modelling and simulation to help our understanding of cellular dynamics, the current practice of experimental design has to chan...